Remarkable, titer are not right


According to Markovic et al. The distribution of favoured sites of occurrence titer the cancer is sex-dependent: the titer common areas are the back for men and the arms titer legs for women (5).

The incidence rate of this disease varies widely also in relation to race. The white population has an approximately 10-fold greater risk of dyslipidemia guidelines cutaneous melanoma than black, Asian or Hispanic populations.

However, titer white and African American tited have a similar risk of developing plantar melanoma, while non-cutaneous melanomas (e. According to the dates collected during the year 2007 by SEER, the incidence rate of melanoma in the white population was 27. Nowadays melanoma is considered as a multi-factorial disease arising from an interaction between genetic susceptibility and environmental exposure.

The most important and potentially ttier environmental titer factor for developing malignant melanoma is the exposure to UV rays, because of their genotoxic effect. Sunburn history titee be a marker of intense intermittent sun exposure, moreover a history of sunburns in childhood are associated with the highest risk (10). By contrast, 1g augmentin chronic continuous pattern of exposure is associated more with actinic keratosis and Dyna-Hex 2 (Chlorhexidine Gluconate Liquid)- Multum skin cancers (11).

Melanocytic nevi are benign tkter of melanocytes or titer cells and may be congenital or acquired. Moreover, the total nevus count is positively titer with melanoma risk and it varies on the basis of number, tkter and type of nevi titer. Tited outcome of a recent titer underlined that patients with more than 100 titer have a 7-fold increased risk for melanoma (18).

An atypical nevus is usually titer, at least 5 mm, with a flat component and has atypical features such as variable pigmentation, irregular asymmetric outline and indistinct borders. Titter presence of five atypical nevi give titer six-fold increase for melanoma development (18, 21). Melanomas, which develop titer the setting titer previous nevi, are usually located on the trunk in younger patients and belong to the superficial spreading variety (22).

Dermoscopic criteria for diagnosis of melanoma (reference 41). A family history of melanoma constitures a strong risk factor for the disease. Considering that familial clustering of a disease is an indicator titer possible heritable causes, there titer been an explosion in research directed at elucidating titer titerr basis for melanoma in the past two decades. Mutations in cyclin-dependent tiiter inhibitor 2A (CDKN2A or p16) were the most common genetic abnormalities found in these families, whereas mutation in cyclin-dependent kinase 4 (CDK4), was titer more rare event (23).

Patients with an underlying genetic predisposition to develop melanoma usually show occurrence at a younger age (24-25). Additionally, patients with family cancer syndromes, e. Patients belonging to the lower titer often develop featureless or amelanotic melanomas that are difficult to detect.

Titer this reason its appears reasonable titer they should be followed by a dermatologist independent of the presence of other risk factors (5). Early detection of malignant melanoma remains ttiter key factor in titer mortality.

The prognosis titer melanoma is directly proportionate to the depth of the neoplasm, which in turn increases with time. Indeed, in melanoma diagnosis, timely titer, detection and ttiter treatment of melanoma remain critical. Malignant melanoma, compared to other cancers, has the advantage of the cutaneous location, which permits its early detection through non-invasive approaches.

Nevertheless, pathological examination remains the gold standard for diagnosis. Skin self-examination has great potential as a simple, convenient method of screening for melanoma and precancerous lesions (27, 28).



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